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Furthermore, I148M oe macrophages had an impaired mitochondrial electron transport chain (ETC) system as reflected by significantly reduced cofactors, FAD and NAD metabolites, as well as genes linked to the ETC complexes, MT-ND1, MT-SHDA, MT-CYTB, MT-CO1, MT-CO2, and ATP6 in both MASH patients and macrophages carrying the PNPLA3 I148M variants, accompanied by reduced mitochondrial ROS production (-15%)

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Toxicol in Vitro 21: 12411246 Wong CH, Bozinovski S, Hertzog PJ, Hickey MJ, Crack PJ (2008) Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion