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Characteristic peri oral melanotic pigmentation more pronounced on the Download Scientific Diagram Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown Unusual Extensive Physiologic Pigmentation of the Tongue: A Case Report Cureus Primary Acquired Melanosis (PAM) Pigmented Conjunctival Cancers (Primary Acquired Melanosis) New York Eye Cancer Center

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