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Free Radic Biol Med (2010) 48:82130

This finding underscores MOTS-cs natural role: when you work out, mitochondria release more MOTS-c, which then helps ramp up energy production and protect cells almost like an internal workout supplement

Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg 2+ , spermine, and pH

extremely wide safety margin in toxicology studies [9] [10]

Given its significant role in brain health and neurotransmitter signalling, low levels of B12 can affect mood regulation, contributing to feelings of sadness or lack of motivation