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Pharmacology Experimental Therapeutics 378, 222234

APIT can be used solo or in conjunction with other modalities and is very effective for alleviating acute or chronic pain, preventing illness, and improving overall body functions.

Nicotine, for instance, transiently alleviates ethanol-induced anhedonia via nicotinic acetylcholine receptor (nAChR) activation but exacerbates withdrawal-related dysphoria (Dohrman and Reiter 2003)