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Cortisol also regulates key gluconeogenic enzymes including PEPCK and G6Pase, whose reduced expression disrupts interconnected glucose and lipid metabolism pathways

By 1951, further refining of thiopurines led to the creation of 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) which were subsequently used to treat children with acute leukemias who up until that point only had corticosteroids and methotrexate available as treatments

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Clinically, this points to a bi-directional interaction between gut inflammation and brain inflammation, with mast cells acting as key transducers in both arenas 24