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Furthermore, our study reveals that metformin can alleviate ECM degradation and inflammation in chondrocytes exposed to H 2 O 2 by reducing oxidative stress-induced damages Additionally, our results establish that metformin exerts its antioxidant effects mainly through the Nrf2 signaling pathway, ultimately slowing OA progression (Fig

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Corresponding clinical trials are currently investigating the efficacy, safety, and therapeutic outcomes of combination regimens involving these targeted inhibitors, with the goal of achieving synergistic antitumor effects and broader clinical benefits