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16: Capping a busy Friday afternoon, the FDA approved AstraZenecas Tagrisso in combination with chemotherapy to treat advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations

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At least 67-75% of nephrons must be lost before increases in sCR levels are seen, therefore a change in sCR is considered a more sensitive marker in late course CKD than in early stage CKD

Noteworthy, as described above, there are significant time-varying arterio-venous differences in BAC (99), but the sampling of arterial, in contrast to venous blood, is challenging and poses an increased risk to study participants

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