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This step should be based on joint fluid biomarkers (such as COMP, CTX-II), and coordinated with physical therapy (strength training, low-frequency pulsed current stimulation, cold and heat therapy, etc.) and drugs (such as NSAIDs, intra-articular injections)

Peng, K., Zhao, X., Fu, Y.-X

It is recommended to take one serving for every 60 kg of body weight one hour before training

As years passed and the correlation between acetaminophen and liver toxicity became even more evident, the FDA convened a meeting to act upon these findings