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Baseline vitamin B12 levels before starting metformin Annual monitoring for patients on long-term metformin therapy Consideration of vitamin B12 supplementation if deficiency is detected Antibiotics and Chemotherapy Agents That Affect B12 Metabolism Certain antibiotics and chemotherapy agents can harm vitamin B12 metabolism

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Research on diet-induced obese mice indicates that fat cell size decreased by approximately 30% and fat volume decreased by around 40%

Ce systme proche de celui des ruminants leur permet de digrer la cellulose et de profiter de la production bactrienne de vitamine B 12 , mais les humains ne le possdent pas [22] , [23]

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