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They are called reactive oxygen species (ROS) or reactive nitrogen species (RNS) and are commonly produced in cells

The salvage study by Safarinejad et al

Cachn-Vega C, et al

In addition, many pathogenic bacteria have evolved not only to survive, but also to thrive in an environment characterized by the oxidative stress caused by infection [55]

However, considering that the hiPSC-derived neurons are cultured in the presence of a higher concentration of glutamine (2 mM) than that used during the incubation experiments (0.5 mM), it is plausible that increased glutamine metabolism in FTD3 neurons is a compensatory mechanism to fuel mitochondria and potentially accelerate ROS production