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The transposed fragments were purified using the Zymo DNA Clean & Concentrator (Zymo Research, USA), eluted in 20 L of H 2 O, and stored at 20 C

doi: 10.1016/j.smim.2019.101324 190 LavivYWangJLAndersonMPKasperEM

doi: 10.1016/j.jid.2018.04.029 265 YangYLZhouCChenQShenSZLiJDWangXLet al

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Pembrolizumab + Trastuzumab + Chemotherapy for HER2-Positive Gastric/GEJ Adenocarcinoma FDA Approval Date: March 19, 2025 The FDA granted full approval to pembrolizumab in combination with trastuzumab and fluoropyrimidine/platinum chemotherapy for first-line treatment of HER2-positive metastatic or unresectable gastric or GEJ adenocarcinoma expressing PD-L1 (CPS 1)