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Understanding the timing of these supplements is not about following a rigid rulebook

In PD, mutations in GBA, ATP13A2, and PARK9 impair lysosomal function, leading to -synuclein accumulation and cellular toxicity ( In particular, LRRK2 mutations impair endolysosomal trafficking, contributing to -synuclein clearance failure and promoting neurodegeneration ( 3 Epidemiology and global burden of Parkinsons disease Parkinsons disease (PD) is one of the fastest-growing neurological disorders globally, driven primarily by population aging, environmental exposures, and improved longevity

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523 Although the relationship between metformin and AD is contradictory, several clinical studies suggest that long-term metformin therapy is associated with a lower risk of neurodegenerative diseases

The majority of TFs contain C2H2 zinc finger domain such as the Dof family, which is involved in photoperiod inducement of flowering and flowering development (Yanagisawa, 2002)