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To determine the underlying mechanism of mitoxyperiosis, Wang and colleagues screened a library of 2050 small molecules, targeting ~1000 cellular pathways

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Aug 14 2020;41(31):2974-2982

Although initially suggested to act via recruiting HDAC3, Xist-mediated silencing is abolished by SHARP deletion, but only attenuated upon HDAC3 deletion 48,49 , suggesting that additional mechanisms are involved in SHARP-dependent repression of the X-chromosome