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In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

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exercises should be more frequent and intensive in patients with an EDSS score of 4.5 and lower, but with modifications can and should be performed in patients with higher EDSS scores