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Description

Living skin has blood circulation that clears delivered molecules at a rate the Franz cell does not capture, and a longer functional half-life of the peptide in tissue is implied but not directly measured

An update to the Metabolism subsection of Section 12.3 Pharmacokinetics now includes information about the specific UGT enzymes (UGT1A3, UGT1A6, UGT1A9, UGT2B7, and UGT2B15) involved in ganaxolone metabolism