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When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment

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Before issuing a final determination, FDA is accepting comments through June 29, 2026

Steroids 2020;163:108701

[12] The common thread is roughly one week , but that figure reflects sleep-laboratory logistics how long you can keep subjects instrumented and funded far more than any biological rationale