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LBP are acute phase reactants that bind to LPS, the outer membrane of Gram-negative bacteria, which is associated with increased markers of barrier permeability, metabolic endotoxemia and systemic inflammation [82]

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Collectively, these observations underscore that the pronounced weight loss caused by GLP-1MK-801 coincides with changes in hypothalamic neuroplasticity and glutamatergic signalling

Similarly, many HSPs themselves have been identified as targets for the treatment of autoimmunity, such as in RA, diabetes, multiple sclerosis (MS), and SLE (165, 166)