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Moreover, sterile water is safe for injection and irrigation purposes, while bacteriostatic water has only been approved for injecting medications and should not come into direct contact with tissues due to possible risk of irritation

All participants received tirzepatide for 36 weeks, alongside diet and exercise support, before being randomly split into two equal-sized groups, one of which continued the medication for a further 52 weeks, while the other switched to a placebo for this period

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Notably, the LTR signaling pathway is involved in the generation of intratumoral HEVs after combined treatment with anti-VEGFR2 and anti-PD-L1