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developed tolcapone-loaded PLGA nanosystem to reduce the hepatotoxic effect of entacapone while retaining its therapeutic efficacy in PD as illustrated in Fig

The whole feeding experiment started on day 95 of gestation and ended on day 14 of lactation

10.17116/jnevro202212207151 68

However, studies such as double-blind clinical trials with larger samples are needed to further demonstrate the efficacy of vitamin D analogs in combination with other traditional therapies in patients with alopecia areata

Gene therapy clinical trials in PD have focused on 4 main targeted approaches: (1) restoring dopamine synthesis, (2) neuroprotection, (3) genetic neuromodulation and (4) addressing disease-specific pathogenic variants (Merola et al