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The sample size of this study is relatively small ( n = 6 per group), which may limit the statistical power to detect subtle changes and represents a limitation of this research

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Interestingly, BSO treatment did not affect SLC25A39 mRNA levels (Extended Data Fig 1c), but could induce SLC25A39 protein accumulation when an SLC25A39 cDNA lacking UTR elements was expressed ectopically under a viral promoter (Extended Data Fig 1d), thereby suggesting regulation at the post-translational level

Expression of ICAM-1, a well-known marker of EC inflammation, was compared among the different groups

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