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A typical physician-directed protocol runs: weeks 1-4 at 1-2% concentration (introductory), weeks 4-12 at 2-5% (standard therapeutic), months 3+ at optimized concentration for ongoing maintenance

10.1038/s41398-025-03521-1 Transl

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The initial inflammatory phase of wound healing, typically lasting 23 days in physiological wounds, is extended in chronic wounds 73

J Lab Clin Med 44:171, 1954