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Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to -lactam antibiotics

72 Previous Study has shown that SAH can reduce the expression of DNA methyltransferase DNMT1 protein, lead to demethylation of the CpG islands in the NF-B gene promoter region, and increase NF-B expression, trigger the expression of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, and thus induce cellular senescence in rat aortic smooth muscle cells

J Antimicrob Chemother 8(Suppl A):1725 Wellman WE, Dodge HW Jr, Heilman FR et al (1954) Concentration of antibiotics in the brain