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NSAIDs NSAIDs are widely utilized in the management of OA due to their efficacy in alleviating pain and inflammation, primarily through the inhibition of COX enzymes, which are crucial for the synthesis of PGs, compounds that mediate inflammation and pain

Finally, the membrane was incubated in SuperSignal West Dura Extended Duration Substrate (Thermo Fisher Scientific Pierce Protein Biology) and imaged with ChemiDocTMTouch Imaging system (BioRad)

Ddit4 fl/fl mice were crossed with Alb-cre mice to generate the hepatocyte-specific DDIT4 knockout ( Ddit4 Hep ) mice, which was verified by the expression of DDIT4 in the primary hepatocyte (Fig

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The search was carried out in two different ways