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DNAzymes have demonstrated well-tolerability in clinical trials targeting c-jun and EBV LMP1 proteins, because these molecules can cross the BBB following systemic injection, eliminating the need for direct brain injections 11

Based on mRNA expression both sequences reduced expression to ~45% of the non-silencing control (nsSiRNA

(32) demonstrated that DFO and deferasirox protect retinal neurons by mitigating Fe 2+ accumulation, reducing the expression of oxidative stress markers, and decreasing RGC loss

Elevated expression of miR18a was confirmed by multiple probes in the array (Appendix Table S3)

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