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Given the widespread use of sunless tanning products and the growing safety concerns, a comprehensive evaluation is necessary

While the specific role of inflammation is beyond the scope of the current study, we hope to continue to follow these patients carefully examine the role of inflammation in this ongoing clinical protocol

*Correspondence: Yasanandana Supunsiri Wijayasinghe, [email protected], Nitesh Kumar Poddar, [email protected], [email protected], Shahanavaj Khan, [email protected] These authors have contributed equally to this work ORCID: Yasanandana Supunsiri Wijayasinghe, Nitesh Kumar Poddar, This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In another RCT ( n = 80), prolonged-release melatonin (PRM 2-mg) therapy showed a significant improvement in sleep hours and reduction in delirium episodes among hospitalized insomniac COVID-19 patients 668

Furthermore, NF-B also has a role in controlling apoptosis 127 and using NF-B, SIRT1 regulates the expression of anti-apoptotic genes 17