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Notably, it has been reported that melatonin MT1 receptors prevent -syninduced ferroptosis in Parkinsons disease through activation of the SIRT1/Nrf2/HO-1/GPX4 pathway [40], which is consistent with our findings and further supports the potential of SIRT1 activation as a strategy to suppress ferroptosis

Liu, X., Lin, J., Zhang, H., Khan, N

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However, the pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles of arsenic metabolites in vivo following oral administration of ATO have not yet been characterized