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For prostanoid generation, both COX-1, which is constitutively expressed by most cells, and COX-2, an inducible isoform upregulated by inflammatory mediators such as lipopolysaccharide, IL-1, IL-6, or tumor necrosis factor- (TNF-), convert AA into prostaglandin endoperoxides (PGs), such as prostaglandin G 2 (PGG 2 ) (Ramsay et al., 2003

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*Correspondence: Wenjuan He, [email protected] Zhou, [email protected] These authors have contributed equally to this work ORCID: Hao Zhou, orcid.org/0000-0002-8411-1589 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers