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doi:10.3233/shti200452

All research must be conducted in accordance with applicable institutional, local, and federal regulations by qualified professionals

The activation of hGPX4-C by compound 102 were remarkably reduced for mutant D23A (the compound concentration required to reach 150% activation was higher than 2,500 M)

Injection : Depending on the clinic, the administration of the solution may be through an intravenous (IV) drip or direct injection

This finding underscores the potential therapeutic value of inhibiting the mtROS/HIF-2 signaling pathway and ameliorating the hypoxic microenvironment to attenuate the detrimental effects of CXCL4 in MS and other CXCL4-driven inflammatory disorders