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The ER is mainly responsible for protein synthesis, processing, and lipid secretion in cells (Oakes and Papa 2015)

Gur A, Karakoc M, Nas K, Cevik R, Sarac J, Ataoglu S: Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial

These results indicate that anchoring the C-terminus of ATG2A to the ER indeed inhibits starvation-induced autophagy

a) Loperamide (Imodium) OTC, most commonly used Acts on -opioid receptors in gut Does not cross BBB no CNS effects b) Diphenoxylate + Atropine (Lomotil) Diphenoxylate slows motility Atropine added to prevent abuse High doses CNS effects Uses: Non-infectious diarrhea (e.g., IBS, travelers diarrhea) Avoid in: Bloody diarrhea, C

Biochimie 100:6177