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Shin et al., 2017)

Mechanistically, glutamine withdrawal can induce rapid apoptosis in Myc-transformed cells, whereas ammonia released from glutamine-catabolizing tumor cells may act in an autocrine or paracrine manner to stimulate autophagy and promote survival under nutrient-limited or hostile microenvironmental conditions (Wise et al., 2008

JM: conceptualization, editing, and final approval

According to the Global Burden of Disease Study 2021, ALS prevalence has increased by nearly 68% between 1990 and 2021, with incidence rising by 74.5% and associated DALYs by 105.5% [1]