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Johnston AD, Abdulrazak A, Sato H, Maqbool SB, Suzuki M, Greally JM, Simes-Pires CA

HIF-1 perpetuates the interaction between synoviocytes and T and B cells, which in turn induces persistent production of inflammatory factors and autoantibodies (188)

Silencing the expression of the endogenous ATF4 showed the opposite results (Figure 5A)

Furthermore, direct GSSG delivery into cells via microinjection induces neural cell death via a 12-lipoxygenase pathway 36

Metabolic regulation of redox balance in ageing Redox reactions occur throughout the cellular metabolism with the production of a small number of reactive oxygen radicals