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Das zentrale theoretische Risiko betrifft die angiogene Wirkung: Da TB-500 die Neubildung von Blutgefen frdert, wird ein mglicher Einfluss auf bestehendes Tumorwachstum diskutiert, ohne dass belastbare Humanevidenz vorliegt

It also replenishes vitamin stores and may be used in the management of certain vitamin B-deficiency states

If each physician deemed it necessary to prescribe a reduced dose of chemotherapy according to clinical manifestations such as age, ECOG-PS, and modestly impaired organ function, it was acceptable for patients to be administered reduced doses even from the first cycle

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It does not reduce circulating DHT levels