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I dont recommend continuous year-round use because receptor downregulation is real, and youll stop seeing benefits (on top of increasing your risk profile unnecessarily)

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Leger B, Derave W, De Bock K, Hespel P, Russell AP (2008) Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation

The endothelium also actively participates in host defense and inflammation by releasing chemokines, which influence various immune cells such as monocytes, neutrophils, eosinophils, and lymphocytes [41]

Liposomal glutathione may be most relevant for individuals with documented oxidative stress biomarkers, those recovering from intensive metabolic interventions, or those managing chronic inflammatory conditions