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Disclosure of interest: No conflict of interests reported Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1085 - ESOC25-222 STROKE AND SMALL VESSEL DISEASE DISRUPT DIURNAL RHYTHMS IN NEUROVASCULAR COUPLING: EVIDENCE FROM THE UK BIOBANK Sheng Yang 1 , Alastair Webb 1 1 Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom Background and Aims: Ischaemic stroke risk is greater in the morning and rate of infarct growth faster at night

Structural research has also explored how cagrilintide interacts with calcitonin and amylin receptors, adding receptor binding detail that helps translate amylin analogue into a clearer mechanistic picture

When -catenin is instead stabilized to increase canonical Wnt signaling activity, otic ectoderm expands at the expense of epibranchial cells (Ohyama et al., 2006)