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Antiestrogenic potentials of ortho-PCB congeners by single or complex exposure

The observation of elevated levels of interleukin-6 and free radicals led the authors to hypothesize that a specific population is predisposed to oxidative stress due to excessive production of type-I interferons and other proinflammatory cytokines (IL-6, IL-12, and TNF-), which in turn stimulate the bone marrow proliferation of HSPCs 20] [21