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Kirenol: A promising bioactive metabolite from siegesbeckia species: a detailed review

47 This triple helix structure, identified as (P(hydroxyl)PG)7, can be further stabilized by the inclusion of a tyrosine (T), thereby increasing its melting temperature

The pharmacokinetic properties of the sulfonamide chosen to be in combination with trimethoprim are important, since relative constancy of the concentrations of the two compounds in the body is desired