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Its effect is mediated through D2 receptors (D2Rs) in the brain, pancreas and pituitary gland thus regulating appetite, circadian rhythms, insulin and prolactin release ( 2.1 Basic science research Investigation of diet impact on PD with research using animal models reveals that high-fat diets worsen nigrostriatal DA depletion in the brain and exacerbate neurotoxicity ( N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins used to induce animal models of PD