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Our group, working with partially deficient IGF-1 mice, has demonstrated that the liver is capable of expressing IGF-1R (which under physiological conditions it does not [99]) as a defence mechanism (peer review)

Non-pharmacologic interventions such as cognitive-behavioral or other types of therapy as a means to ease symptom burden and help manage the stress of living with a chronic illness may be useful as well

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism team

Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomized clinical trial

They need to stay refrigerated (36-46 degrees Fahrenheit or 2-8 degrees Celsius) until first use