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doi: 10.1038/mt.2012.66 157 StoesselD.SchulteC.TeixeiraD

Changes to the 2 position group can affect nucleic acid stability and affinity, 227 with common modifications including 2-fluoro (2-F), 2-O-methoxyethyl (2-MOE), and 2-O-methyl (2-OMe)