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While the passive technique focuses on drug and vehicle interaction and optimization to affect the stratum corneum structure, the active approach utilizes external energy to facilitate the transportation of drugs through the skin or by physically disrupting the outermost layer of the skin, known as the stratum corneum [230, 231]

A., Bovy, R

10.1038/ni.2001 Nat Immunol

[DOI] [PMC free article] [PubMed] [Google Scholar] lvarez-Benedicto E., Farbiak L., Mrquez Ramrez M., Wang X., Johnson L.T., Mian O., Guerrero E.D., Siegwart D.J

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