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16,17 In addition, those who experience constipation throughout their lives appear to be at increased risk
PMID 10812052
Third, most inhibitors of NLRP3, NF-B, autophagy, ferroptosis, or senescence remain preclinical and lack regulatory approval, and there is a paucity of validated pharmacodynamic biomarkers in humans (e.g., CSF IL-1/IL-18, GSDMD-N, ex vivo NLRP3 assays) to confirm target engagement
