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doi: 10.1016/j.jaad.2018.04.036

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There was a significant reduction in total cancer incidence (105 vs 137 cases, P = 0.03), prostate cancer (22 vs 42 cases, P = 0.005), a marginally significant reduction in colorectal cancer incidence (9 vs 19 cases, P = 0.057), and a reduction in cancer mortality, all cancer sites (40 vs 66 deaths, P = 0.008) (selenium versus control group cases reported, respectively) [98]

25-30 Metabolism of Synthetic Opioids Synthetic opioid metabolism also often occurs through the CYP450 enzyme system, with varying responsible enzymes (see table below)