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While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)

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Role of PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers

So they did a study, for example, and they found that if there were empty wrappers, like in the environment, people would eat more because they were assuming that other people had eaten it

Tyagi C, Bathke J, Goyal S et al (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence