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The answer involves MTHFR mutations

(2.1) Recommended daily dosage is based on patient's actual weight (2.2) Less than 1 kg: The daily dose is 1.5 mL 1 kg to 3 kg: The daily dose is 3.25 mL 3 kg or more: The daily dose is 5 mL One daily dose of the reconstituted solution (1.5 mL, 3.25 mL or 5 mL) is then added directly to the intravenous fluid (2.2,2.3) See Full Prescribing Information for reconstitution instructions (2.3) Monitor blood vitamin concentrations (2.4) See Full Prescribing Information for drug incompatibilities (2.5) Dosage Forms and Strengths Contraindications Warnings and Precautions Risk of Aluminum Toxicity: Aluminum may reach toxic levels with prolonged administration

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Mekontso-Dessap A , Houl R , Soustelle C , Kirsch M , Thbert D , Loisance DY

For most people, hitting their intake of B12 is easy, but for those who follow a vegetarian or vegan diet diet, where does B12 come from