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Based on the evidence provided by Evidence Development and Standards and its partners, the Ontario Health Technology Advisory Committeea standing advisory subcommittee of the Health Quality Ontario Boardmakes recommendations about the uptake, diffusion, distribution, or removal of health interventions to Ontarios Ministry of Health and Long-Term Care, clinicians, health system leaders, and policy-makers

Therefore, additional research is needed to validate the impact of a reduced amino acid intake in patients with cancer

Funding The authors are grateful for the support of NIH grants R01NS039587, R01NS086423 and R01HD102071

Supplementary Materials The following supporting information can be downloaded at: Figure S1: 3D structure of bovine xanthine oxidase (XO), protein cleaved form

Fedwick et al