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Pica can also be a behavioural problem, particularly in intensively confined animals

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cut-offs range from 150 pmol/L to 300 pmol/L for deficiency. Such heterogeneity makes pooled analysis difficult and may hide true relationships

Systematic collection of adverse events was not done in all of these studies and interpretation of causality is limited due to the lack of a control group and due to circumstances of administration (e.g., use in fire victims)