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Mechanism of action Acitretin exerts its effects by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to gene transcription changes that mediate its anti-proliferative and anti-inflammatory properties

(2006) Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion Physiol

But such claims have been controversial and there are several factors to consider when critically reviewing the results of these studies

10.3389/fneur.2021.763419 Front

Clear correlation with the luteal phase: Symptoms consistently worsen during the luteal phase , when progesterone peaks, and are absent or significantly improved during the follicular phase when progesterone is low