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It protects the CNS from neurotoxins and pathogens by regulating the exchange of substances between the blood and brain tissue [379], playing a pivotal role in maintaining CNS homeostasis [380]

Kelidari, H

doi: 10.7759/cureus.40948 42 JonesRMMercanteJWNeishAS

2019;29(6):1090-1095 Meyer AC

For example, allergen exposure in animal models is completely different from natural allergen exposure and the immune response of allergic patients is far different from experimental animal studies