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Among these cells, some function as tumor-associated immune cells, including immature/tolerogenic dendritic cells (DCs), M2 macrophages, regulatory T cells and myeloid-derived suppressor cells (98)

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Indeed, combination of exome, transcriptome, and metabolome analyses of multiple NSCLC cell lines also clearly demonstrated that remarkable enhancement of glutamate excretion, cystine uptake, and glutathione synthesis is a striking and reproducible feature of NRF2-addicted cancer cells (Saigusa et al