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Mitochondrial biogenesis Mitochondrial biogenesis is tightly controlled by nuclear-encoded transcriptional regulators, notably peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), nuclear factor erythroid 2-related factors 1/2 (NRF1/2), and yin yang 1 (YY1), which coordinate mtDNA transcription and replication through effectors such as TFAM and POLRMT [22, 23]

When exposed to bile acids, ME-3 survived for 24 hours without significant loss of live bacteria. Thus, Lactobacillus fermentum ME-3 can tolerate exposure to harsh acidity in the stomach as well as exposure to bile acids in the small intestine

Dangardt, F

USA 106 , 2193021935 (2009)

In a complex digested sample, co-elution (from online-HPLC) and co-isolation (at MS1) of peptides with others with a similar m/z result can result in a combination of the reporter ion intensity from different peptides, resulting in a bias in the relative ratio of a peptide from different proteomes